Specific Jak3 Downregulation in Lymphocytes Impairs γc Cytokine Signal Transduction and Alleviates Antigen-driven Inflammation In Vivo

Jak3, one of the four members comprising the Jak family of cytosolic tyrosine kinases, has emerged as a promising target for nontoxic immunotherapies. Although a number of Jak inhibitors has already demonstrated efficacy, they suffer from secondary effects apparently associated to their pan-Jak acti...

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Detalhes bibliográficos
Main Authors: Gómez-Valadés, Alicia G, Llamas, María, Blanch, Sílvia, Perales, José C, Román, Juan, Gómez-Casajús, Lluís, Mascaró, Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464880/
https://ncbi.nlm.nih.gov/pubmed/23344234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.37
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