The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas

BACKGROUND: Fatty acid synthase (FASN) is overexpressed and associated with poor prognosis in several human cancers. Here, we investigate the effect of FASN inhibitors on the metastatic spread and angiogenesis in experimental melanomas and cultured melanoma cells. METHODS: The lung colonisation assa...

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Detalhes bibliográficos
Main Authors: Seguin, F, Carvalho, M A, Bastos, D C, Agostini, M, Zecchin, K G, Alvarez-Flores, M P, Chudzinski-Tavassi, A M, Coletta, R D, Graner, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464771/
https://ncbi.nlm.nih.gov/pubmed/22892389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.355
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