Retargeting Sleeping Beauty Transposon Insertions by Engineered Zinc Finger DNA-binding Domains

The Sleeping Beauty (SB) transposon is a nonviral, integrating vector system with proven efficacy in preclinical animal models, and thus holds promise for future clinical applications. However, SB has a close-to-random insertion profile that could lead to genotoxic effects, thereby presenting a pote...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Voigt, Katrin, Gogol-Döring, Andreas, Miskey, Csaba, Chen, Wei, Cathomen, Toni, Izsvák, Zsuzsanna, Ivics, Zoltán
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2012
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464645/
https://ncbi.nlm.nih.gov/pubmed/22776959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.126
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