Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA

Viral double-stranded RNA, a ligand for Toll-like Receptor 3 (TLR3) and the cytoplasmic RNA receptors RIG1 and MDA5, activate a signaling network in which the IKK-related protein kinase TBK1 phosphorylates the transcription factor Interferon Regulatory Factor 3 (IRF3) and the E3 ubiquitin ligase Pel...

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Autors principals: Enesa, Karine, Ordureau, Alban, Smith, Hilary, Barford, David, Cheung, Peter C. F., Patterson-Kane, Janet, Arthur, J. Simon C., Cohen, Philip
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464584/
https://ncbi.nlm.nih.gov/pubmed/22902624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.367557
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