HTLV-2 Tax Immortalizes Human CD4(+) Memory T Lymphocytes by Oncogenic Activation and Dysregulation of Autophagy

Human T cell leukemia virus type 1 and type 2 (HTLV-1 and -2) are two closely related retroviruses with the former causing adult T cell leukemia. HTLV-2 infection is prevalent among intravenous drug users, and the viral genome encodes the viral transactivator Tax, which is highly homologous to the t...

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Detalhes bibliográficos
Main Authors: Ren, Tong, Dong, Wen, Takahashi, Yoshinori, Xiang, Di, Yuan, Yunsheng, Liu, Xin, Loughran, Thomas P., Sun, Shao-Cong, Wang, Hong-Gang, Cheng, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464572/
https://ncbi.nlm.nih.gov/pubmed/22891252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.377143
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