Mitochondrial Ca(2+) Uptake 1 (MICU1) and Mitochondrial Ca(2+) Uniporter (MCU) Contribute to Metabolism-Secretion Coupling in Clonal Pancreatic β-Cells

In pancreatic β-cells, uptake of Ca(2+) into mitochondria facilitates metabolism-secretion coupling by activation of various matrix enzymes, thus facilitating ATP generation by oxidative phosphorylation and, in turn, augmenting insulin release. We employed an siRNA-based approach to evaluate the ind...

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Hlavní autoři: Alam, Muhammad Rizwan, Groschner, Lukas N., Parichatikanond, Warisara, Kuo, Liang, Bondarenko, Alexander I., Rost, Rene, Waldeck-Weiermair, Markus, Malli, Roland, Graier, Wolfgang F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464549/
https://ncbi.nlm.nih.gov/pubmed/22904319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.392084
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