A Flexible Multidomain Structure Drives the Function of the Urokinase-type Plasminogen Activator Receptor (uPAR)

The urokinase-type plasminogen activator receptor (uPAR) provides a rendezvous between proteolytic degradation of the extracellular matrix and integrin-mediated adhesion to vitronectin. These processes are, however, tightly linked because the high affinity binding of urokinase regulates the binding...

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Main Authors: Mertens, Haydyn D. T., Kjaergaard, Magnus, Mysling, Simon, Gårdsvoll, Henrik, Jørgensen, Thomas J. D., Svergun, Dmitri I., Ploug, Michael
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464537/
https://ncbi.nlm.nih.gov/pubmed/22896701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.398404
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