KCNQ1 Channels Do Not Undergo Concerted but Sequential Gating Transitions in Both the Absence and the Presence of KCNE1 Protein

The co-assembly of KCNQ1 with KCNE1 produces I(KS), a K(+) current, crucial for the repolarization of the cardiac action potential. Mutations in these channel subunits lead to life-threatening cardiac arrhythmias. However, very little is known about the gating mechanisms underlying KCNQ1 channel act...

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Bibliografiske detaljer
Main Authors: Meisel, Eshcar, Dvir, Meidan, Haitin, Yoni, Giladi, Moshe, Peretz, Asher, Attali, Bernard
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Membrane Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464529/
https://ncbi.nlm.nih.gov/pubmed/22908235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.364901
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