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Disease-Associated Mutations Disrupt Functionally Important Regions of Intrinsic Protein Disorder
The effects of disease mutations on protein structure and function have been extensively investigated, and many predictors of the functional impact of single amino acid substitutions are publicly available. The majority of these predictors are based on protein structure and evolutionary conservation...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3464192/ https://ncbi.nlm.nih.gov/pubmed/23055912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002709 |
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