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High sensitivity detection of cancer in vivo using a dual-controlled activation fluorescent imaging probe based on H-dimer formation and pH activation

The key to improving the sensitivity of in vivo molecular imaging is to increase the target-to-background signal ratio (TBR). Optical imaging has a distinct advantage over other molecular imaging methods in that the fluorescent signal can be activated at the target thus reducing background signal. P...

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Autors principals: Ogawa, Mikako, Kosaka, Nobuyuki, Regino, Celeste A. S., Mitsunaga, Makoto, Choyke, Peter L., Kobayashi, Hisataka
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464101/
https://ncbi.nlm.nih.gov/pubmed/20567775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b917876g
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