Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells

Most cases of cystic fibrosis (CF) are caused by the deletion of a single phenylalanine residue at position 508 of the cystic fibrosis transmembrane conductance regulator (CFTR). The mutant F508del-CFTR is retained in the endoplasmic reticulum and degraded, but can be induced by low temperature incu...

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Autori principali: Zhang, Donglei, Ciciriello, Fabiana, Anjos, Suzana M., Carissimo, Annamaria, Liao, Jie, Carlile, Graeme W., Balghi, Haouaria, Robert, Renaud, Luini, Alberto, Hanrahan, John W., Thomas, David Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Research Foundation 2012
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463858/
https://ncbi.nlm.nih.gov/pubmed/23060796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00176
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