PEI-Engineered Respirable Particles Delivering a Decoy Oligonucleotide to NF-κB: Inhibiting MUC2 Expression in LPS-Stimulated Airway Epithelial Cells

A specific and promising approach to limit inflammation and mucin iperproduction in chronic lung diseases relies on specific inhibition of nuclear Factor-κB (NF-κB) by a decoy oligonucleotide (dec-ODN). To fulfill the requirements dictated by translation of dec-ODN therapy in humans, inhalable dry p...

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Detalhes bibliográficos
Main Authors: Ungaro, Francesca, De Stefano, Daniela, Giovino, Concetta, Masuccio, Alessia, Miro, Agnese, Sorrentino, Raffaella, Carnuccio, Rosa, Quaglia, Fabiana
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463602/
https://ncbi.nlm.nih.gov/pubmed/23056313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046457
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