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A Series of Beta-Carboline Derivatives Inhibit the Kinase Activity of PLKs
Polo-like kinases play an essential role in the ordered execution of mitotic events and 4 mammalian PLK family members have been identified. Accumulating evidence indicates that PLK1 is an attractive target for anticancer drugs. In this paper, a series of beta-carboline derivatives were synthesized...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463587/ https://ncbi.nlm.nih.gov/pubmed/23056340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046546 |
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