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The Liberation of CD44 Intracellular Domain Modulates Adenoviral Vector Transgene Expression
The success of gene therapy in the ocular environment is partly due to the presence of hyaluronan in vitreous. Here we explore the mechanism of hyaluronan-mediated enhancement of adenoviral vector transgene expression. Introduction of hyaluronan receptor CD44 into CD44-negative cells followed by tra...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463356/ https://ncbi.nlm.nih.gov/pubmed/22865879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.347369 |
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