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Hyaluronan-CD44v3 Interaction with Oct4-Sox2-Nanog Promotes miR-302 Expression Leading to Self-renewal, Clonal Formation, and Cisplatin Resistance in Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma

Human head and neck squamous cell carcinoma (HNSCC) is a highly malignant cancer associated with major morbidity and mortality. In this study, we determined that human HNSCC-derived HSC-3 cells contain a subpopulation of cancer stem cells (CSCs) characterized by high levels of CD44v3 and aldehyde de...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bourguignon, Lilly Y. W., Wong, Gabriel, Earle, Christine, Chen, Liqun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463333/
https://ncbi.nlm.nih.gov/pubmed/22847005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.308528
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