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Hyaluronan-CD44v3 Interaction with Oct4-Sox2-Nanog Promotes miR-302 Expression Leading to Self-renewal, Clonal Formation, and Cisplatin Resistance in Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma
Human head and neck squamous cell carcinoma (HNSCC) is a highly malignant cancer associated with major morbidity and mortality. In this study, we determined that human HNSCC-derived HSC-3 cells contain a subpopulation of cancer stem cells (CSCs) characterized by high levels of CD44v3 and aldehyde de...
Wedi'i Gadw mewn:
Prif Awduron: | , , , |
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Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
American Society for Biochemistry and Molecular Biology
2012
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Pynciau: | |
Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463333/ https://ncbi.nlm.nih.gov/pubmed/22847005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.308528 |
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