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Hyaluronan-CD44 Interaction Activates Stem Cell Marker Nanog, Stat-3-mediated MDR1 Gene Expression, and Ankyrin-regulated Multidrug Efflux in Breast and Ovarian Tumor Cells

Hyaluronan (HA) is a major glycosaminoglycan in the extracellular matrix whose expression is tightly linked to multidrug resistance and tumor progression. In this study we investigated HA-induced interaction between CD44 (a HA receptor) and Nanog (an embryonic stem cell transcription factor) in both...

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Bibliographische Detailangaben
Hauptverfasser: Bourguignon, Lilly Y. W., Peyrollier, Karine, Xia, Weiliang, Gilad, Eli
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427357/
https://ncbi.nlm.nih.gov/pubmed/18441325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800109200
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