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Electrophilic Aldehydes Generated by Sperm Metabolism Activate Mitochondrial Reactive Oxygen Species Generation and Apoptosis by Targeting Succinate Dehydrogenase

Oxidative stress is a major cause of defective sperm function in cases of male infertility. Such stress is known to be associated with high levels of superoxide production by the sperm mitochondria; however, the causes of this aberrant activity are unknown. Here we show that electrophilic aldehydes...

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Autori principali: Aitken, R. John, Whiting, Sara, De Iuliis, Geoffry N., McClymont, Samantha, Mitchell, Lisa A., Baker, Mark A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463304/
https://ncbi.nlm.nih.gov/pubmed/22851170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.366690
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