Astragaloside IV Inhibits Oxidative Stress-Induced Mitochondrial Permeability Transition Pore Opening by Inactivating GSK-3β via Nitric Oxide in H9c2 Cardiac Cells

Objective. This study aimed to investigate whether astragaloside IV modulates the mitochondrial permeability transition pore (mPTP) opening through glycogen synthase kinase 3β (GSK-3β) in H9c2 cells. Methods. H9c2 cells were exposed to astragaloside IV for 20 min. GSK-3β (Ser(9)), Akt (Ser(473)), an...

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Detalhes bibliográficos
Main Authors: He, Yonggui, Xi, Jinkun, Zheng, Huan, Zhang, Yidong, Jin, Yuanzhe, Xu, Zhelong
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463196/
https://ncbi.nlm.nih.gov/pubmed/23050041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/935738
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