Tauroursodeoxycholic acid inhibits endoplasmic reticulum stress, blocks mitochondrial permeability transition pore opening, and suppresses reperfusion injury through GSK-3ß in cardiac H9c2 cells

This study investigates whether inhibition of endoplasmic reticulum (ER) stress prevents opening of the mitochondrial permeability transition pore (mPTP) and evaluates the corresponding signaling pathways involved in this process. Exposure of cardiac H9c2 cells to 800 µM H(2)O(2) for 20 min opened m...

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Опубликовано в: :Am J Transl Res
Главные авторы: Xie, Yuxi, He, Yonggui, Cai, Zhiliang, Cai, Jianhang, Xi, Mengyao, Zhang, Yidong, Xi, Jinkun
Формат: Artigo
Язык:Inglês
Опубликовано: e-Century Publishing Corporation 2016
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126306/
https://ncbi.nlm.nih.gov/pubmed/27904664
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