Tauroursodeoxycholic acid inhibits endoplasmic reticulum stress, blocks mitochondrial permeability transition pore opening, and suppresses reperfusion injury through GSK-3ß in cardiac H9c2 cells

This study investigates whether inhibition of endoplasmic reticulum (ER) stress prevents opening of the mitochondrial permeability transition pore (mPTP) and evaluates the corresponding signaling pathways involved in this process. Exposure of cardiac H9c2 cells to 800 µM H(2)O(2) for 20 min opened m...

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Detalhes bibliográficos
Publicado no:Am J Transl Res
Main Authors: Xie, Yuxi, He, Yonggui, Cai, Zhiliang, Cai, Jianhang, Xi, Mengyao, Zhang, Yidong, Xi, Jinkun
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126306/
https://ncbi.nlm.nih.gov/pubmed/27904664
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