Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes

The PRH/Hhex transcription factor represses multiple genes in the VEGF signalling pathway (VSP) to inhibit myeloid cell survival. Protein kinase CK2 phosphorylates PRH and counteracts the inhibitory effect of this protein on cell survival by blocking the repression of VSP genes. Here we show that th...

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Hlavní autoři: Noy, Peter, Gaston, Kevin, Jayaraman, Padma-Sheela
Médium: Artigo
Jazyk:Inglês
Vydáno: Pergamon Press 2012
Témata:
Brief Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462996/
https://ncbi.nlm.nih.gov/pubmed/22874537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2012.07.013
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