Isomerization of an Antimicrobial Peptide Broadens Antimicrobial Spectrum to Gram-Positive Bacterial Pathogens

The branched M33 antimicrobial peptide was previously shown to be very active against Gram-negative bacterial pathogens, including multidrug-resistant strains. In an attempt to produce back-up molecules, we synthesized an M33 peptide isomer consisting of D-aminoacids (M33-D). This isomeric version s...

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Bibliografiske detaljer
Main Authors: Falciani, Chiara, Lozzi, Luisa, Pollini, Simona, Luca, Vincenzo, Carnicelli, Veronica, Brunetti, Jlenia, Lelli, Barbara, Bindi, Stefano, Scali, Silvia, Di Giulio, Antonio, Rossolini, Gian Maria, Mangoni, Maria Luisa, Bracci, Luisa, Pini, Alessandro
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462775/
https://ncbi.nlm.nih.gov/pubmed/23056272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046259
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