In vitro and in vivo efficacy, toxicity, bio-distribution and resistance selection of a novel antibacterial drug candidate

A synthetic antimicrobial peptide was identified as a possible candidate for the development of a new antibacterial drug. The peptide, SET-M33L, showed a MIC(90) below 1.5 μM and 3 μM for Pseudomonas aeruginosa and Klebsiella pneumoniae, respectively. In in vivo models of P. aeruginosa infections, t...

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Udgivet i:Sci Rep
Main Authors: Brunetti, Jlenia, Falciani, Chiara, Roscia, Giulia, Pollini, Simona, Bindi, Stefano, Scali, Silvia, Arrieta, Unai Cossio, Gómez-Vallejo, Vanessa, Quercini, Leila, Ibba, Elisa, Prato, Marco, Rossolini, Gian Maria, Llop, Jordi, Bracci, Luisa, Pini, Alessandro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864329/
https://ncbi.nlm.nih.gov/pubmed/27169671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26077
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