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Thrombospondin-1 (TSP1)–Null and TSP2-Null Mice Exhibit Lower Intraocular Pressures

PURPOSE. Thrombospondin-1 (TSP1) and TSP2 are matricellular proteins that have been shown to regulate cytoskeleton, cell adhesion, and extracellular matrix remodeling. Both TSP1 and TSP2 are found in the trabecular meshwork (TM). In cadaver eyes with primary open-angle glaucoma (POAG), TSP1 is incre...

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Detalhes bibliográficos
Main Authors: Haddadin, Ramez I., Oh, Dong-Jin, Kang, Min Hyung, Villarreal, Guadalupe, Kang, Ja-Heon, Jin, Rui, Gong, Haiyan, Rhee, Douglas J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462480/
https://ncbi.nlm.nih.gov/pubmed/22930728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-9013
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