Superantigenic Activity of emm3 Streptococcus pyogenes Is Abrogated by a Conserved, Naturally Occurring smeZ Mutation

Streptococcus pyogenes M/emm3 strains have been epidemiologically linked with enhanced infection severity and risk of streptococcal toxic shock syndrome (STSS), a syndrome triggered by superantigenic stimulation of T cells. Comparison of S. pyogenes strains causing STSS demonstrated that emm3 strain...

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Main Authors: Turner, Claire E., Sommerlad, Mary, McGregor, Karen, Davies, Frances J., Pichon, Bruno, Chong, Deborah L. W., Farzaneh, Leili, Holden, Matthew T. G., Spratt, Brian G., Efstratiou, Androulla, Sriskandan, Shiranee
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462185/
https://ncbi.nlm.nih.gov/pubmed/23049698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046376
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