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The cytochrome P-450-depleted animal: an experimental model for in vivo studies in chemical biology.

An experimental method is described to deplete markedly in vivo the cytochrome P-450 content of liver for prolonged periods of time. The method uses the synthetic metalloporphyrin cobalt-heme (cobalt protoporphyrin IX), which possesses the dual biological properties of repressing delta-aminolevulina...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Drummond, G S, Kappas, A
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1982
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346198/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6954546/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.7.2384
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