SOX2 regulates the hypothalamic-pituitary axis at multiple levels

Sex-determining region Y (SRY) box 2 (SOX2) haploinsufficiency causes a form of hypopituitarism in humans that is characterized by gonadotrophin deficiency known as hypogonadotrophic hypogonadism. Here, we conditionally deleted Sox2 in mice to investigate the pathogenesis of hypogonadotrophic hypogo...

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Détails bibliographiques
Auteurs principaux: Jayakody, Sujatha A., Andoniadou, Cynthia L., Gaston-Massuet, Carles, Signore, Massimo, Cariboni, Anna, Bouloux, Pierre M., Le Tissier, Paul, Pevny, Larysa H., Dattani, Mehul T., Martinez-Barbera, Juan P.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461924/
https://ncbi.nlm.nih.gov/pubmed/22945632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64311
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