Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans

Wingless (Wnt)/β-catenin signaling plays an essential role during normal development, is a critical regulator of stem cells, and has been associated with cancer in many tissues. Here we demonstrate that genetic expression of a degradation-resistant mutant form of β-catenin in early Rathke's pou...

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Detalhes bibliográficos
Main Authors: Gaston-Massuet, Carles, Andoniadou, Cynthia Lilian, Signore, Massimo, Jayakody, Sujatha A., Charolidi, Nicoletta, Kyeyune, Roger, Vernay, Bertrand, Jacques, Thomas S., Taketo, Makoto Mark, Le Tissier, Paul, Dattani, Mehul T., Martinez-Barbera, Juan Pedro
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136310/
https://ncbi.nlm.nih.gov/pubmed/21636786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101553108
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