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Using Reaction Mechanism to Measure Enzyme Similarity

The concept of reaction similarity has been well-studied in terms of the overall transformation associated with a reaction, but not in terms of mechanism. We present the first method to give a quantitative measure of the similarity of reactions based upon their explicit mechanisms. Two approaches ar...

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Detalhes bibliográficos
Main Authors: O’Boyle, Noel M., Holliday, Gemma L., Almonacid, Daniel E., Mitchell, John B.O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461574/
https://ncbi.nlm.nih.gov/pubmed/17400244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.02.065
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