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Phosphorus-containing inhibitors of angiotensin-converting enzyme.

Several phosphonamides, phosphoramides, and phosphates having the general structure R-Y-P(O)(OH)-X-CH(CH3)-CO-Pro have been synthesized and tested for inhibition of angiotensin-converting enzyme (dipeptidyl carboxypeptidase; peptidyl-dipeptide hydrolase, EC 3.4.15.1). Inhibition was found to depend...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Thorsett, E D, Harris, E E, Peterson, E R, Greenlee, W J, Patchett, A A, Ulm, E H, Vassil, T C
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1982
Schlagworte:
Research Article
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346153/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6285369/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.7.2176
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