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Antibody repertoire development in fetal and neonatal piglets. XXII. λ rearrangement precedes κ rearrangement during B-cell lymphogenesis in swine

VDJ and VJ rearrangements, expression of RAG-1, Tdt and VpreB, and the presence of signal joint circles (SJC) were used to identify sites of B-cell lymphogenesis. VDJ, VλJλ but not VκJκ rearrangements or SJC were recovered from yolk sac (YS) at 20 days of gestation (DG) along with strong expression...

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Détails bibliographiques
Auteurs principaux: Sun, Xiuzhu, Wertz, Nancy, Lager, Kelly, Sinkora, Marek, Stepanova, Katerina, Tobin, Gregory, Butler, John E
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461396/
https://ncbi.nlm.nih.gov/pubmed/22724577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2012.03615.x
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