Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis

MLN4924, a newly discovered small molecule inhibitor of NEDD8-activating enzyme (NAE), inactivates Cullin-RING E3 ubiquitin Ligases (CRLs) by blocking cullin neddylation. As a result, MLN4924 causes accumulation of several key substrates of CRLs and effectively suppresses tumor cell growth by induci...

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Detalhes bibliográficos
Main Authors: Zhao, Y, Xiong, X, Jia, L, Sun, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461362/
https://ncbi.nlm.nih.gov/pubmed/22951983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.125
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