A Designed Functional Metalloenzyme that Reduces O(2) to H(2)O with Over One Thousand Turnovers

[Image: see text] Rational design of functional enzymes with high turnovers is a significant challenge, especially those with complex active site and difficult reactions, such as in respiratory oxidases. Introducing 2 His and 1 Tyr into myoglobin resulted in designed enzymes that reduce O(2) to H(2)...

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Detalhes bibliográficos
Main Authors: Miner, Kyle D., Mukherjee, Arnab, Gao, Yi-Gui, Null, Eric L., Petrik, Igor D., Zhao, Xuan, Yeung, Natasha, Robinson, Howard, Lu, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461324/
https://ncbi.nlm.nih.gov/pubmed/22539151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201201981
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