WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma

BACKGROUND: Medulloblastoma is the most common malignant childhood brain tumour. Aberrant activation of the WNT/β-catenin pathway occurs in approximately 25% of medulloblastomas. However, its role in medulloblastoma pathogenesis is not understood. METHODS: We have developed a model of WNT/β-catenin...

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Detalhes bibliográficos
Main Authors: Rogers, H A, Sousa, S, Salto, C, Arenas, E, Coyle, B, Grundy, R G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461168/
https://ncbi.nlm.nih.gov/pubmed/22929883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.377
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