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An Early Reduction in Treg Cells Correlates with Enhanced Local Inflammation in Cutaneous Leishmaniasis in CCR6-Deficient Mice
Resistance to Leishmania major infection is dependent on the development of a cell-mediated Th1 immune response in resistant C57BL/6 mice whereas Th2-prone BALB/c mice develop non-healing lesions after infection. The chemokine receptor CCR6 is shared by anti-inflammatory regulatory T cells and pro-i...
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Main Authors: | , , , , , , |
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Format: | Artigo |
Language: | Inglês |
Published: |
Public Library of Science
2012
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Subjects: | |
Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3460949/ https://ncbi.nlm.nih.gov/pubmed/23028548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044499 |
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