Molecular Characterisation of Endogenous Vangl2/Vangl1 Heteromeric Protein Complexes

BACKGROUND: Mutations in the Planar Cell Polarity (PCP) core gene Vangl2 cause the most severe neural tube defects (NTD) in mice and humans. Genetic studies show that the Vangl2 gene genetically interacts with a close homologue Vangl1. How precisely Vangl2 and Vangl1 proteins interact and crosstalk...

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Autors principals: Belotti, Edwige, Puvirajesinghe, Tania M., Audebert, Stéphane, Baudelet, Emilie, Camoin, Luc, Pierres, Michel, Lasvaux, Lea, Ferracci, Géraldine, Montcouquiol, Mireille, Borg, Jean-Paul
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460870/
https://ncbi.nlm.nih.gov/pubmed/23029439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046213
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