TLR signaling augments macrophage bactericidal activity through mitochondrial ROS

Reactive oxygen species (ROS) are essential components of the innate immune response against intracellular bacteria, and it is thought that professional phagocytes generate ROS primarily via the phagosomal NADPH oxidase (Phox) machinery(1). However, recent studies have suggested that mitochondrial R...

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Detalhes bibliográficos
Main Authors: West, A. Phillip, Brodsky, Igor E., Rahner, Christoph, Woo, Dong Kyun, Erdjument-Bromage, Hediye, Tempst, Paul, Walsh, Matthew C., Choi, Yongwon, Shadel, Gerald S., Ghosh, Sankar
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460538/
https://ncbi.nlm.nih.gov/pubmed/21525932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09973
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