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The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases

The class 1 PI3Ks are lipid kinases with key roles in cell surface receptor-triggered signal transduction pathways. Two isoforms of the catalytic subunits, p110γ and p110δ, are enriched in leucocytes in which they promote activation, cellular growth, proliferation, differentiation and survival throu...

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Detalhes bibliográficos
Main Authors: Banham-Hall, Edward, Clatworthy, Menna R, Okkenhaug, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: Bentham Open 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460535/
https://ncbi.nlm.nih.gov/pubmed/23028409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1874312901206010245
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