The Heme Oxygenase 1 Inducer (CoPP) Protects Human Cardiac Stem Cells against Apoptosis through Activation of the Extracellular Signal-regulated Kinase (ERK)/NRF2 Signaling Pathway and Cytokine Release

Intracoronary delivery of c-kit-positive human cardiac stem cells (hCSCs) is a promising approach to repair the infarcted heart, but it is severely limited by the poor survival of donor cells. Cobalt protoporphyrin (CoPP), a well known heme oxygenase 1 inducer, has been used to promote endogenous CO...

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Main Authors: Cai, Chuanxi, Teng, Lei, Vu, Duc, He, Jia-Qiang, Guo, Yiru, Li, Qianghong, Tang, Xian-Liang, Rokosh, Gregg, Bhatnagar, Aruni, Bolli, Roberto
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
主題:
Cell Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460469/
https://ncbi.nlm.nih.gov/pubmed/22879597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.385542
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