Ubiquitination and Degradation of the Hominoid-Specific Oncoprotein TBC1D3 Is Mediated by CUL7 E3 Ligase

Expression of the hominoid-specific TBC1D3 oncoprotein enhances growth factor receptor signaling and subsequently promotes cellular proliferation and survival. Here we report that TBC1D3 is degraded in response to growth factor signaling, suggesting that TBC1D3 expression is regulated by a growth fa...

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Detalhes bibliográficos
Main Authors: Kong, Chen, Samovski, Dmitri, Srikanth, Priya, Wainszelbaum, Marisa J., Charron, Audra J., Liu, Jialiu, Lange, Jeffrey J., Chen, Pin-I, Pan, Zhen-Qiang, Su, Xiong, Stahl, Philip D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459922/
https://ncbi.nlm.nih.gov/pubmed/23029530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046485
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