The Hominoid-specific Oncogene TBC1D3 Activates Ras and Modulates Epidermal Growth Factor Receptor Signaling and Trafficking

Hominoid- and human-specific genes may have evolved to modulate signaling pathways of a higher order of complexity. TBC1D3 is a hominoid-specific oncogene encoded by a cluster of eight paralogs on chromosome 17. Initial work indicates that TBC1D3 is widely expressed in human tissues (Hodzic, D., Kon...

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Detalhes bibliográficos
Main Authors: Wainszelbaum, Marisa J., Charron, Audra J., Kong, Chen, Kirkpatrick, Donald S., Srikanth, Priya, Barbieri, M. Alejandro, Gygi, Steven P., Stahl, Philip D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442359/
https://ncbi.nlm.nih.gov/pubmed/18319245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800234200
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