Confidence-based Somatic Mutation Evaluation and Prioritization

Next generation sequencing (NGS) has enabled high throughput discovery of somatic mutations. Detection depends on experimental design, lab platforms, parameters and analysis algorithms. However, NGS-based somatic mutation detection is prone to erroneous calls, with reported validation rates near 54%...

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Dettagli Bibliografici
Autori principali: Löwer, Martin, Renard, Bernhard Y., de Graaf, Jos, Wagner, Meike, Paret, Claudia, Kneip, Christoph, Türeci, Özlem, Diken, Mustafa, Britten, Cedrik, Kreiter, Sebastian, Koslowski, Michael, Castle, John C., Sahin, Ugur
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459886/
https://ncbi.nlm.nih.gov/pubmed/23028300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002714
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