Fabrication and characterization of nuclear localization signal-conjugated glycol chitosan micelles for improving the nuclear delivery of doxorubicin

BACKGROUND: Supramolecular micelles as drug-delivery vehicles are generally unable to enter the nucleus of nondividing cells. In the work reported here, nuclear localization signal (NLS)-modified polymeric micelles were studied with the aim of improving nuclear drug delivery. METHODS: In this resear...

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Dades bibliogràfiques
Autors principals: Yu, Jingmou, Xie, Xin, Zheng, Meirong, Yu, Ling, Zhang, Lei, Zhao, Jianguo, Jiang, Dengzhao, Che, Xiangxin
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2012
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459689/
https://ncbi.nlm.nih.gov/pubmed/23049255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S36150
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