Ligand-dependent Degradation of Smad3 by a Ubiquitin Ligase Complex of ROC1 and Associated Proteins

Smads are signal mediators for the members of the transforming growth factor-β (TGF-β) superfamily. Upon phosphorylation by the TGF-β receptors, Smad3 translocates into the nucleus, recruits transcriptional coactivators and corepressors, and regulates transcription of target genes. Here, we show tha...

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Main Authors: Fukuchi, Minoru, Imamura, Takeshi, Chiba, Tomoki, Ebisawa, Takanori, Kawabata, Masahiro, Tanaka, Keiji, Miyazono, Kohei
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2001
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC34595/
https://ncbi.nlm.nih.gov/pubmed/11359933
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