Metronomic Ceramide Analogs Inhibit Angiogenesis in Pancreatic Cancer through Up-regulation of Caveolin-1 and Thrombospondin-1 and Down-regulation of Cyclin D1

AIMS: To evaluate the antitumor and antiangiogenic activity of metronomic ceramide analogs and their relevant molecular mechanisms. METHODS: Human endothelial cells [human dermal microvascular endothelial cells and human umbilical vascular endothelial cell (HUVEC)] and pancreatic cancer cells (Capan...

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Bibliografische gegevens
Hoofdauteurs: Bocci, Guido, Fioravanti, Anna, Orlandi, Paola, Di Desidero, Teresa, Natale, Gianfranco, Fanelli, Giovanni, Viacava, Paolo, Naccarato, Antonio Giuseppe, Francia, Giulio, Danesi, Romano
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Neoplasia Press Inc. 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459279/
https://ncbi.nlm.nih.gov/pubmed/23019415
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