Adenosine A(2B) receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity

BACKGROUND: Neuroprotective and neurotrophic properties of leukemia inhibitory factor (LIF) have been widely reported. In the central nervous system (CNS), astrocytes are the major source for LIF, expression of which is enhanced following disturbances leading to neuronal damage. How astrocytic LIF e...

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Hauptverfasser: Moidunny, Shamsudheen, Vinet, Jonathan, Wesseling, Evelyn, Bijzet, Johan, Shieh, Chu-Hsin, van Ijzendoorn, Sven CD, Bezzi, Paola, Boddeke, Hendrikus WGM, Biber, Knut
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458985/
https://ncbi.nlm.nih.gov/pubmed/22894638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-198
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