The mammalian PYHIN gene family: Phylogeny, evolution and expression

BACKGROUND: Proteins of the mammalian PYHIN (IFI200/HIN-200) family are involved in defence against infection through recognition of foreign DNA. The family member absent in melanoma 2 (AIM2) binds cytosolic DNA via its HIN domain and initiates inflammasome formation via its pyrin domain. AIM2 lies...

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Hauptverfasser: Cridland, Jasmyn A, Curley, Eva Z, Wykes, Michelle N, Schroder, Kate, Sweet, Matthew J, Roberts, Tara L, Ragan, Mark A, Kassahn, Karin S, Stacey, Katryn J
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458909/
https://ncbi.nlm.nih.gov/pubmed/22871040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-12-140
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