Determinants of the selective toxicity of alloxan to the pancreatic B cell.
The diabetogenic agent alloxan exerts a preferential cytotoxic effect on the pancreatic B cell. The determinants of such a tissue specificity were investigated. Alloxan accumulated rapidly in liver and pancreatic islets but much more slowly in muscle. The activity of glutathione peroxidase and the r...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1982
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC345866/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7038690/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.3.927 |
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