Determinants of the selective toxicity of alloxan to the pancreatic B cell.

The diabetogenic agent alloxan exerts a preferential cytotoxic effect on the pancreatic B cell. The determinants of such a tissue specificity were investigated. Alloxan accumulated rapidly in liver and pancreatic islets but much more slowly in muscle. The activity of glutathione peroxidase and the r...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Malaisse, W J, Malaisse-Lagae, F, Sener, A, Pipeleers, D G
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1982
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC345866/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7038690/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.3.927
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