TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1

The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topoisomerase is covalently linked to the 3′- or 5′-terminus of a DNA strand break. This type of DNA damage is implicated in chromosome translocations and neurological disease and underlies the cl...

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Bibliographische Detailangaben
Hauptverfasser: Zeng, Zhihong, Sharma, Abhishek, Ju, Limei, Murai, Junko, Umans, Lieve, Vermeire, Liesbeth, Pommier, Yves, Takeda, Shunichi, Huylebroeck, Danny, Caldecott, Keith W., El-Khamisy, Sherif F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458563/
https://ncbi.nlm.nih.gov/pubmed/22740648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks622
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