TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1

The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topoisomerase is covalently linked to the 3′- or 5′-terminus of a DNA strand break. This type of DNA damage is implicated in chromosome translocations and neurological disease and underlies the cl...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Zeng, Zhihong, Sharma, Abhishek, Ju, Limei, Murai, Junko, Umans, Lieve, Vermeire, Liesbeth, Pommier, Yves, Takeda, Shunichi, Huylebroeck, Danny, Caldecott, Keith W., El-Khamisy, Sherif F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458563/
https://ncbi.nlm.nih.gov/pubmed/22740648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks622
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky